Human IgG4 Binds to IgG4 and Conformationally Altered IgG1 via Fc-Fc Interactions
نویسندگان
چکیده
منابع مشابه
Human IgG4 binds to IgG4 and conformationally altered IgG1 via Fc-Fc interactions.
The Fc fragment of IgG4 can interact with the Fc fragment of another IgG molecule. This interaction is a confounding factor when measuring IgG4 rheumatoid factor levels. Recently, we demonstrated that half-molecules of IgG4 can exchange to form a bispecific Ab. We expected these two phenomena to be related and investigated the physicochemical aspects of IgG4 Fc-Fc interactions. We found that Ig...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2009
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.0804338